Acta Metallurgica Sinica (English Letters) ›› 2022, Vol. 35 ›› Issue (12): 2069-2081.DOI: 10.1007/s40195-022-01435-1

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Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function

Yangyang Yan1,2, Na Li3, Feng Guo1,2, Anhua Wu4, Wei Jin1,2, Rui Yang1,2, Yun Bai1,2(), Xing Zhang1,2()   

  1. 1Shi-Changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China
    2School of Materials Science and Engineering, University of Science and Technology of China, Shenyang, 110016, China
    3College of Life Science and Engineering, Shenyang University, Shenyang, 110044, China
    4Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
  • Received:2022-01-12 Revised:2022-03-29 Accepted:2022-04-07 Online:2022-12-10 Published:2022-07-03
  • Contact: Yun Bai,Xing Zhang
  • About author:Xing Zhang, xingzhang@imr.ac.cn
    Yun Bai, ybai@imr.ac.cn;

Abstract:

Intracranial vascular stenting has been widely used for ischemic stroke. However, there are complication risks with stent implantation, such as poor wall apposition, stent migration, thromboembolism and stent restenosis, due to the mismatched radial force and conformability of the stents. Therefore, a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization function. The bending moment of the stents was calculated to be 0.346 N mm, which shows improved conformability. The radial force of the stents evaluated by the flat plate test was 0.0112 N/mm, within the range of the commercially available stent force (0.0065-0.0116 N/mm). Furthermore, the Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation, adhesion and migration of human umbilical vein endothelial cells in vitro. The nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation.

Key words: Nitinol stents, Conformability, Radial force, Endothelialization, Intracranial stenosis treatment