Acta Metallurgica Sinica (English Letters) ›› 2022, Vol. 35 ›› Issue (12): 2069-2081.DOI: 10.1007/s40195-022-01435-1
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Yangyang Yan1,2, Na Li3, Feng Guo1,2, Anhua Wu4, Wei Jin1,2, Rui Yang1,2, Yun Bai1,2(), Xing Zhang1,2(
)
Received:
2022-01-12
Revised:
2022-03-29
Accepted:
2022-04-07
Online:
2022-12-10
Published:
2022-07-03
Contact:
Yun Bai,Xing Zhang
About author:
Xing Zhang, xingzhang@imr.ac.cnYangyang Yan, Na Li, Feng Guo, Anhua Wu, Wei Jin, Rui Yang, Yun Bai, Xing Zhang. Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function[J]. Acta Metallurgica Sinica (English Letters), 2022, 35(12): 2069-2081.
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Stent ID | Length-to-width ratio | Cell structure |
---|---|---|
Stent-A | 2 | SD cell |
Stent-B | 1.5 | SD cell |
Stent-C | 1 | SD cell |
Stent-D | 1 | DD cell |
Stent-E | 1 | SD + DD cell |
Stent-F | 2/1.5/1 | SD cell |
Stent-G | 2/1.5/1 | DD cell |
Stent-H | 2/1.5/1 | SD + DD cell |
Table 1 Eight designed stents with different length-to-width ratios and cell structures
Stent ID | Length-to-width ratio | Cell structure |
---|---|---|
Stent-A | 2 | SD cell |
Stent-B | 1.5 | SD cell |
Stent-C | 1 | SD cell |
Stent-D | 1 | DD cell |
Stent-E | 1 | SD + DD cell |
Stent-F | 2/1.5/1 | SD cell |
Stent-G | 2/1.5/1 | DD cell |
Stent-H | 2/1.5/1 | SD + DD cell |
Fig. 2 Conformability and ovalization of designed stents: a a schematic diagram of the three-point bending test, b bending moment-displacement curves of Stent-A, B and C with SD cell structure during the loading-unloading process for different length-to-width ratios (1, 1.5, 2), c bending moment-displacement curves of Stent-C, D and E with cell length-to-width ratio 1 during the loading-unloading process, d eccentricity of Stent-A-Stent-E for ovalization analysis, e representative bending moment-displacement curves of Stent-F,G and H during the loading-unloading process, f eccentricity of Stent-F, G and H for ovalization analysis
Fig. 3 FEA of the “Flat Plate Test” simulation of stents: a a schematic diagram of the “Flat Plate Test” simulation, and the radial force per unit length-displacement curves of b Stent-C and D, c Stent-F, G and H with the variation of cell length-to-width ratios during the loading-unloading process
Fig. 4 Dimension verification and composition of laser-cut stents: a whole stent image, b SD cell, and DD cell structure of the stent, c, d partial enlarged view, e chemical composition of the stent measured by EDS
Fig. 8 Growth of HUVECs on NiTi and NiTi-GYIGSR sample surfaces. a OD values from HUVECs cultured on control group (NiTi, dark blue column) and NiTi-GYIGSR group (light dark column) for 24 h and 72 h evaluated by CCK-8. b, c Analysis of HUVECs cultured on NiTi (control group) and NiTi-GYIGSR sample surfaces by in vitro migration assay: images were acquired at 48 h of culture after creating a detection zone with the tip of sterilized pipette and ruler. The dashed lines on the images are used as guides for the initial cell free zone and green spots represented live cells. SEM micrographs of HUVECs morphology after culture for 24 h d-g and 72 h h-k: d, h NiTi sample surfaces (control group), e, i magnified region of interest. f, j NiTi-GYIGSR sample surfaces, g, k magnified region of interest
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