Acta Metallurgica Sinica (English Letters) ›› 2016, Vol. 29 ›› Issue (12): 1098-1106.DOI: 10.1007/s40195-016-0493-z

Special Issue: 2016纳米材料专辑

• Orginal Article • Previous Articles     Next Articles

Facile Development of Iron-Platinum Nanoparticles to Harness Multifunctionality in Single Entity

Madhulekha Gogoi1,3(),Komanduri S. Varadarajan2,Anant Bahadur Patel2,Pritam Deb1   

  1. 1. Department of Physics, Tezpur University (Central University), Tezpur, Assam 784028, India
    2. NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Habsiguda, Hyderabad 500007, India
    3. Present Address: Department of Chemistry, IIT Guwahati,North Guwahati, Assam 781039, India;
  • Received:2016-05-24 Online:2016-11-22 Published:2016-11-22

Abstract:

Engineered magnetic nanosystems exhibit attractive options for implementing unique diagnostic options and therapeutic solutions in biomedical applications. Here we report a facile, thermo-free and aqueous synthetic method to prepare ascorbic acid-stabilized iron-platinum nanoparticles. The effects of reducing agent, pH and sequence of precursor addition are investigated, and optimized reaction condition is identified to obtain a unique iron-platinum (Pt-FePt) nanosystems. The multifunctionality of the developed nanosystem has been realized by catalytic efficiency of platinum for therapeutic application and superparamagnetic property of FePt for magnetic resonance imaging contrast enhancement. Moreover, the multifunctional imaging and therapeutic activities have been achieved at physiological pH. The developed multifunctional nanoparticles are monodisperse with uniform morphology as well as stable in solution and non-toxic.

Key words: Multifunctional, Superparamagnetic, Magnetic resonance imaging (MRI), Therapeutic